Department of Biomedical Technology, Nám. Sítná 3105, Kladno, 272 01
Our research team is focused on basic as well as applied research into the possibilities of using EM (electromagnetic) field in the biomedicine. The research is focused not only on therapeutic but also on diagnostic applications of EM field in medicine. Another important activity of this team is research of positive and negative interactions of electromagnetic field with living organisms and setting of safe limits for population exposure to electromagnetic field.
Who we are?
prof. Ing. Peter Kneppo, DrSc. doc. Dr.-Ing. Jan Vrba, M.Sc., doc. Ing. David Vrba, Ph.D., Mgr. Ksenia Sedova,Ph.D., Mgr. Elena Deutsch, Ing. Ondřej Fišer, Ing. Luis Felipe Díaz, Ing. Jan Tesařík
- Vrba, D., Vrba, J., Rodrigues, D. B., Stauffer, P., “Numerical Investigation of Novel Microwave Applicators Based on Zero-Order Mode Resonance for Hyperthermia Treatment of Cancer,“ Journal of the Franklin Institute – In Press. IF = 2.395. Available online at: http://dx.doi.org/10.1016/j.jfranklin.2016.10.044 \
- Vrba, D., Rodrigues, D. B., Vrba, J., and Stauffer, P. R., "Metamaterial antenna arrays for improved uniformity of microwave hyperthermia treatments," Progress In Electromagnetics Research, Vol. 156, 1-12, 2016. IF = 1.229.
- Punshchykova, O., Švehlíková, J., Tyšler, M., Grünes, R., Sedova, K., Osmančík, P., Žďárská, J., Heřman, D., Kneppo, P. "Influence of Torso Model Complexity on the Noninvasive Localization of Ectopic Ventricular Activity ". Measurement Science Review, vol. 16, no. 2, p. 96-102, 2016. ISSN 1335-8871. IF = 0.989
- Vrba, J., Karch J., and Vrba D., „Microwave Glucose Monitoring in Aqueous- and Blood-Glucose Solutions: In Vitro Feasibility Study,” International Journal of Antennas and Propagation, Vol. 2015, 2015, Article ID 570870, 5 pages, ISSN 1687-5869. IF = 0.827.
- Vrba, J., Vrba, D., “A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring,” Radioengineering. 2015, vol. 2015, no. 4, p. 877-884. ISSN 1210-2512. IF = 0.653.
- Dario B. Rodrigues, Paul R. Stauffer, David Vrba and Mark D. Hurwitz, The use of therapy ultrasound in treatment and pain palliation of bone tumors, International Journal of Hyperthermia vol. 31, no. 3, p. 260-271 ISSN 0265-6736, IF 2.769
- Sedova K, Bernikova O, Azarov J, Shmakov D, Vityazev V, Kharin S. Effects of echinochrome on ventricular repolarization in acute ischemia. J Electrocardiol 2015. 48(2): 181-6. IF 1.363
2012 - 2014
- Vrba, D., Vrba, J., “Novel Applicators for Local Microwave Hyperthermia Based on Zeroth-Order Mode Resonator Metamaterial,” International Journal of Antennas and Propagation, Vol. 2014, 2014. ISSN 1687-5869. IF = 0.827.
- Vrba, J., Vrba, D., “Temperature and Frequency Dependent Empirical Models of Dielectric Properties of Sunflower and Olive Oil,” Radioengineering, vol. 22., no. 4, 2013. IF = 0.798.
- Pokorny, J., Foletti, A., Kobilkova, J., Jandova, A., Vrba, J., Vrba, J., Nedbalova, M., Cocek, A., Danani, A. Tuszynski, J. A., “Biophysical Insights into Cancer Transformation and Treatment,” Sci. World J., vol. 2013, Jun. 2013. IF = 1.219.
- Weiss, R., Weiss, M., Beasley, K., Vrba, J., Bernardy, J., “Operator Independent Focused High Frequency ISM Band for Fat Reduction: Porcine Model,” Lasers Surg. Med., vol. 45, no. 4, pp. 235–239, 2013. IF = 2.611.
- Vrba, J., Jansen, R. H., Diewald, A. and Baum, G., “Investigation of electromagnetic field radiation and substrate mode excitation caused by microstrip via structures,” Journal of Electromagnetic Waves and Applications, vol. 26, no. 13, pp. 1779–1787, 2012.
- Polívka, M. - Vrba, D.: Input Resistance of Electrically Short Not-too-Closely Spaced Multi-Element Monopoles with Uniform Current Distribution. IEEE Antennas and Wireless Propagation Letters. 2012, vol. 11, no. 1, p. 1592-1595. ISSN 1536-1225. IF 1.948
- Titomir, Leonid I., and Peter Kneppo. Bioelectric and Biomagnetic Fields: Theory and Applications in Electrocardiology. CRC, 1994.
- L. I. Titomir, P. Kneppo,“ Mathematical Simulation of the Bioelectrical Heart Generator“, Moscow: Fizmatlit, 2000, 448 pp., ISBN: 5-02-015245-5.
- L. I. Titomir, P. Kneppo , V. G. Trunov, E. A. – I. Aidu,“Biophysical Foundations of Electrocardiotopographic Methods“, Moscow: Fizmatlit, 2009, 236 pp., ISBN: 978-5-9221-1162-1.
- BRAIN Team FBME
Department of Biomedical Technology, Nám. Sítná 3105, Kladno, 272 01
Biosignal Recognition & Artificial Inteligence in Neuroscience
The research team is currently involved in the processing and analysis of EEG records. Measurement of brain electrical activity is used in clinical practice as a diagnostic method. It is used for example in the detection of epilepsy, in the analysis of sleep states and memory consolidation. In addition to clinical practice, EEG is processed and evaluated in research. The research area requires other methods of signal analysis, for example for group measurements. The research team is engaged in processing and analysis of human and animal EEG
Who we are?
Our research team is focused on basic and applied research of methods and processes for EEG analysis in animal and human subjects.
Doc. Ing. Vladimir Krajca, CSc. : He has a practically oriented basis in research and development of original systems and methodology for computer-aided processing and analysis of biological signals, including implementation in clinical practice.
Ing. Václava Piorecká: She deals with the analysis of animal records and the creation of modalities for evaluating group measurements in animal experiments.
Ing. Marek Piorecký: He deals with the classification of EEG records using non-learning density classifiers. Involved in the simultaneous measurement of EEG-fMRI, including the processing and analysis of records.
Ing. Hana Schaabová: She deals with the analysis of EEG signals using artificial intelligence algorithms, for example to assist doctors in processing long-term epileptic EEG records.
Ing. Jan Štrobl: He deals with the removal of artifacts from the long-term EEG record. It also focuses on simultaneous recording of EEG and fMRI and inverse role in rat brain.
WHAT WE COOPERATE
- M. Bares, M. Brunovsky, M. Kopecek, T. Novak, P. Stopkova, J. Kozeny, P. Sos, V. Krajca, C. Höschl. Early reduction in prefrontal theta QEEG cordance value predicts response to venlafaxine treatment in patients with resistant depressive disorder. European Psychiatry. 23, 5, pp 350-355, 2008. (51 citací), IF 3.912.
- Krajča V., Petránek S., Patáková I., Värri A., Automatic identificaton of significant graphoelements in multichannel EEG recordings by adaptive segmentation and fuzzy clustering, Int. J. Biomed.Comput.,28 (1991) pp.71-89. (49 citací), IF 0.446.
- Horacek J, Brunovsky M, Novak T,Skrdlantova L, Klirova M., Bubenikova V., Krajca V. Tislerova B., Kopecek M., Spaniel F., Mohr P., Hoschl C. Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations. Neuropsychobiology 55 (3-4): 132-142 2007, (47 citací), IF 1.763.
- Bares M, Novak T, Brunovsky M, Kopecek M, Stopkova P, Krajca V, Höschl C. The change of QEEG prefrontal cordance as a response predictor to antidepressive intervention in bipolar depression. A pilot study. Journal of Psychiatric Research 46 (2012), 219-225. (32 citací) IF 4.664.
- Brunovský M., Matoušek M., Edman A., Červená K., Krajča V., Objective assessment of the degree of dementia by means of EEG, Neuropsychobiology 2003; 48: 19-26. (30 citací), IF 1.479.
- Witte H., Eiselt M., Patakova I., Petranek S., Griessbach H., Krajca V., Rother M., Use of discrete Hilbert transformation for automatic spike mapping : a methodological investigation, Medical and Biological Eng. & Computing, 1991, 29 ,242-248. (28 citací), IF. 1.004.
- Paul K., Krajča V., Roth Z., Melichar J., Petránek S., Comparison of quantitative EEG characteristics of quiet and active sleep in newborns, Sleep Medicine 4, (2003), pp. 543-552. (25 citací), IF 2.711.
- T Páleníček, M. Fujáková, M. Brunovský,M. Balíková, Jiří Horáček, I. Gorman , F.Tylš , B. Tišlerová, P. Šoš, V. Bubeníková-Valešová, C. Höschl ,V. Krajča. Electroencephalographic Spectral and Coherence Analysis of Ketamine in Rats: Correlation with Behavioral Effects and Pharmacokinetics. Neuropsychobiology 2011;63:202–218. (24 citací) IF. 2.147.
- Zima M., Tichavský P, Paul K, and KrajčaV. Robust removal of short-duration artifacts in long neonatal EEG recordings using wavelet-enhanced ICA and adaptive combining of tentative reconstructions. Physiological Measurement vol. 33, 8, pp.39-49, 2012. (15 citací), IF 1.677.
- V. Gerla, K. Paul, L. Lhotska, and V. Krajca. Multivariate Analysis of Full-Term Neonatal Polysomnographic Data. IEEE Transaction on Information Technology in Biomedicine, vol .13, no.1,pp. 104-110 (2009) (15 citací), IF 1.694.
Department of Information and Communication Technologies in Medicine, Studničkova 7/2028 Praha 2
Who we are?
Multidisciplinary research team composed of experts from FBME CTU, CIIRK CTU and 1st Faculty of Medicine, Charles University.
Pavel Smrčka, Tomáš Veselý, Martin Vítězník, Radim Kliment, Lukáš Kučera, Jan Kašpar, Karel Hána, Jan Mužík, Markéta Janatová, Tomáš Nedělka
What research we do?
Measuring, transmission, on-line processing, imaging, archiving and off-line processing of biological signals in real time. We specialize in research and experimental development of telemetric systems for professional monitoring in stress conditions, eg in athletes, soldiers and firefighters using the wearable electronics.
The promotional video shots of the scientific team:
Examples of realized systems:
VLV 3 - portable medical polygraphic unit – measuring and on-line Wifi streaming of ECG, breath curve, activity, body temperature, skin resistance from up to 12 persons simultaneously. Includes advanced multiplatform software. The primary use of the device is to support research in biology, psychology, human research etc. The system enables monitoring individual physiological responses to various stimuli.
FlexiGuard - Personal security surveillance system to support training and intervention of Integrated Rescue System units. Enables long-term telemetric monitoring of health-physiological data and the environment in real time – heart rate, body and environmental temperature, physical activity, humidity, body position, breath frequency, GPS position. Can monitor up to 30 persons simultaneously and transfer the data up to 1 km.
Who we cooperate with?
- Department of Rehabilitation Medicine, 1.LF UK a VFN
- Neurological clinics, Faculty Hospital Motol - doc. MUDr. Jaroslav Jeřábek, CSc.
- Clever Technologies, s.r.o., spin-off firma FBMI ČVUT a 1.LF UK v Praze
- CASRI - Vědecké a servisní pracoviště tělesné výchovy a sportu
- Technical Univerzity Košice – Department of Aviation
- and many other
- Hána, K.; Kašpar, J.; Kučera, L.; Mužík, J.; Smrčka, P.; Veselý, T.; Vítězník, M.: Surveillance equipment for monitoring persons, especially indifficult conditions and the system of sensor placement on the human body. Patent CZ 307930. 2019-07-17.
- Hlavinka, P.; Šebelka, Z.; Hána, K.; Kašpar, J.; Mužík, J.; Smrčka, P.: Method of three-stage communication of the notification center and the end element of the warning. Patent CZ 307931. 2019-07
- Kašpar, J.; Hon, Z.; Janatová, M.; Smrčka, P.; Vítězník, M.; Hána, K.; Veselý, T.; Mužík, J. A biotelemetric system for the support of monitoring the psychophysiological state of a human being Czech Republic. Patent. CZ 306895. 2017-07-19.
- Bittner, R. - Hána, K. - Poušek, L. - Schreib, P. - Smrčka, P. - et al.: Method of detection and signalization of the drivers fatigue during the driving task and the method of it's realization. Patent, Úřad průmyslového vlastnictví, č.300170. 2009-03-04.
- Hána, K. - Smrčka, P. - Nešvera, L. - Holčík, J. - Fiala, R. - et al.: The device for the measuring and/or monitoring and/or analysis of the physiological signals acquired from the horse body. Patent, Úřad průmyslového vlastnictví, č.301867. 2010-07-14.
- Smrčka, P. - Hána, K. - Kašpar, J. - Brada, J.: Device for the measuring of the temperature in the MRI measuring chamber. Patent, Úřad průmyslového vlastnictví, č.302506. 2011-05-11.
- Kašpar, J. – Hon, Z. - Jantová, M. – Smrčka, P – et al.: A biotelemetric system for the support of monitoring the psychophysiological state of a human being, Patent, Úřad průmyslového vlastnictví, č. 306895. 2016-07-07.
Recent journal publications:
- Sajtaroa, L; Janatova, M ; Vesely, T; Lopotova, M; Smrcka, P; Hana, K: A randomized controlled study of the effect of balance disorder therapy using audiovisual feedback on senior citizens, Ceska a Slovenska Neurologie a Neurochirurgie, 2020, Volume: 83 Issue: 1 Pages: 101-104, ISSN: 1210-7859 . WOS:000514084800014
- Adamová, B.; Kutílek, P.; Cakrt, O.; Svoboda, Z.; Vítečková, S.; Smrčka, P.: Quantifying postural stability of patients with cerebellar disorder during quiet stance using three-axis accelerometer , Biomedical Signal Processing and Control. 2018, 40 378-384. ISSN 1746-8094. WOS:000418211300041.
- Kliment, R.; Smrčka, P.; Hána, K.; Schlenker, J.; Socha, V.; Socha, L.; Kutílek, P.: Wearable Modular Telemetry System for the Integrated Rescue System Operational Use , Journal of Sensors. 2017, 2017 ISSN 1687-725X. WOS:000399940000001
- Kutílek, P.; Volf, P.; Vítečková, S.; Smrčka, P.; Lhotská, L.; Hána, K.; Krivanek, V.; Doskocil, R. et al.: Wearable Systems and Methods for Monitoring Psychological and Physical Condition of Soldiers , Advances in Military Technology. 2017, 12(2), 259-280. ISSN 1802-2308. Scopus 2-s2.0-85038639447
- Hon, Z.; Smrčka, P.; Hána, K.; Kašpar, J.; Mužík, J.; Fiala, R.; Vítězník, M.; Veselý, T. et al.: A Survelliance System for Enhancing the Safety of Rescue Teams, Communications. 2015, 17(1), 81-86. ISSN 1335-4205. Scopus 2-s2.0-84921859878
- Kutílek, P.; Vítečková, S.; Svoboda, Z.; Socha, V.; Smrčka, P.: Kinematic quantification of gait asymmetry based on characteristics of angle-angle diagrams , Acta Polytechnica Hungarrica. 2014, 11(5), 25-38. ISSN 1785-8860. WOS:000321327400013
- Kutílek, P.; Vítečková, S.; Svoboda, Z.; Smrčka, P.: Kinematic quantification of gait asymmetry in patients with peroneal nerve palsy based on bilateral cyclograms , Journal of Musculoskeletal & Neuronal Interactions. 2013, 13(2), 244-250. ISSN 1108-7161.WOS:000321327400013.
- Trefny, ZM; Svacinka, J.; Kittnar, O.; Slavicek, J.; Trefny, M.; Filatova, E.; Tichy, JA; Smrčka, P. et al.: Quantitative Ballistocardiography (Q-BCG) for Measurement of Cardiovascular Dynamics, Physiological Research. 2011, 60(4), 617-625. ISSN 0862-8408. WOS:000295057100004
Health technology assessment for medical devices
Department of Biomedical Technology, nám. Sítná 3105, Kladno, 272 01
The CzechHTA research team has their own web page at
Who are we?
We are a group focused on health technology assessment (HTA), where we primarily focus on examining the clinical and economic benefits of various health interventions. Within HTA we concentrate on HTA applied to medical devices and equipment in the conditions of the Czech Republic. Our research methods are cost-effectiveness analysis, including modeling and simulation tools.
Our team's areas of interest also include healthcare delivery and financing systems, economics and healthcare management
What do we do?
- Research focused on HTA, economy and management of health services
- Teaching the master study field Systematic integration of processes in health services
- Expert reports in the area of purchase and operation of medical devices
Interaction of XUV radiation with biological objects
Department of Natural Sciences, nám. Sítná 3105, Kladno, 272 01
Prof. Ing. Miroslava Vrbová, CSc.
XUV radiation is electromagnetic radiation with wave lengths of 1-100 nm. It is very strongly absorbed by the atmosphere and the majority of substances in our surroundings. Therefore, we do not get in contact with natural sources of this radiation in ordinary life. Significant potential implementation of XUV radiation is expected mainly in new technologies and in biology. Technological applications include mainly lithographic procedures in the production of highly integrated electronic elements, whereas in biology research covers the imaging of small objects, such as cells, and photophysical phenomena. The best known sources of XUV radiation are synchrotrons. Alternative sources whose research is currently highly accentuated are laser plasma and a high-voltage electrical discharge.
New trends in disaster medicine
Department of Health Care Disciplines and Population Protection, nám. Sítná 3105, Kladno, 272 01
prof. MUDr. Leoš Navrátil CSc. MBA, dr.h.c.
doc. Mgr. Zdeněk Hon Ph.D.
Ing. Hana Kličková
Key research directions of the Department of Health Care and Population Protection
Who are we?
The team of experts at the Department of Health Care and Population Protection focuses mainly on population protection and its safety. We have a multidisciplinary team gathered at the department, from doctors, rescuers, toxicologists, radiobiologists to experts in technical and informational sciences and specialists in security issues.
Research team members
Prof. MUDr. Věra Adámková, CSc., Assoc. Prof. PhDr. Ludmila Čírtková, CSc., Mgr. Monika Donevová, Ing. Yulie Efremova, Ph.D., Ing. Markéta Janů, Ing. Jiří Halaška, Ph.D., Assoc. Prof. Mgr. Zdeněk Hon, Ph.D., Ing. Jana Hudzietzová, Ph.D., Ing. Hana Kličková, Prof. MUDr. Leoš Navrátil, CSc., MBA, dr.h.c., Ing. Václav Navrátil, Ing. Roman Říha, Ing. Martin Staněk, Prof. Ing. Josef Tlustý, CSc., PhDr. Barbora Vegrichtová, Ph.D., MBA
Designed research projects
Detection of Radicalization in the Context of Population and Soft Targets Protection from Violent Incidents
solver: Assist. Prof. PhDr. Barbora Vegrichtová, Ph.D., MBA
This research project identifies and evaluates the security threat of radicalization and processes the sophisticated methods and measures for detection and prevention of this phenomena in the context soft target population protection. Further, the project ensures increasing the awareness of specialized employees of security bodies and other relevant professional, especially pedagogues, social workers, lecturers and related persons via educational software, lecturing methods and pedagogical activities.
Increasing the resistance of the region against the threat of a general power failure. energy using new technologies and crisis management procedures
solver Assoc. Prof. Ing. Zdeněk Müller, Ph.D., head of Department of Electrical Power Engineering of Faculty of Electrical Engineering of Czech Technical University in Prague
responsible for the FBMI Assist. Prof. Ing. Jiří Halaška, Ph.D.
This project focuses on the complex and system-wide preparation to combat a wide area blackout threat, the transition to island operation and the subsequent renewal using newly created instruments and methods of population protection and crisis management. It focuses on problem solution in areas with high population density. The project covers two closely related areas - technical infrastructure and the follow-up
development of new emergency and crisis processes.
Healthcare Facilities Protection against Terrorist Attacks
solver: Assist. Prof. Ing. Markéta Janů
This project is focused on the analysis of the current protection levels of healthcare inpatient facilities against terrorist attacks. In the course ofthis project information about the protection and preparedness of healthcare inpatient facilities is obtained in order to combat a terrorist attack. The University Hospital in the Czech Republic and countries of the European Union are examined. The obtained information will be analyzed and compared. The outcome of this study will be an evaluation of the current preparedness of healthcare inpatient facilities against terrorist attacks and presentation of an optimal solution to increase the safety of these facilities.
The IRS members' Motivation and Couple Relationships
solver: Ing. Roman Říha
This project has two parts. The goal of the first one is to study and statistically process data about stress factors of Emergency line operators, which also affect their partners. The second part looks into the motivation of voluntary firemen in Central Bohemia. For both parts, several types of surveys will be used, aimed at anamnestic data, subjective workload perception and partner life, with the addition of the motivations of voluntary fireman in the second part. The research is supported by the Medical Rescue Services, the Police of the Czech Republic and the Fire Rescue Service of the Czech Republic.
Assessing the threat of exposure of firefighters to combustion products
solver: Mgr. Petr Kožený
In the case of fire, a considerable amount of combustion products is generated. Consequently, the fire equipment, the means of fire protection and the firefighters themselves are exposed to contamination. Exposure of firefighters to combustion products occurs not only at the scene of the fire, but also when returning to a fire station. While in Europe and all over the world there are procedures of maintaining the means of fire protection contaminated by chemical, biological, nuclear or radioactive noxious substances, the maintenance of the means of fire protection contaminated by combustion products are often underestimated. Contaminants released from these agents are toxic or carcinogenic and may adversely affect the health of firefighters. Some studies also suggest that firefighters are more likely to suffer from some forms of cancer than the rest of the population. Research aimed at better understanding of where and why the highest exposure of firefighters occur may contribute to lowering its level.
Non-conventional Ventilatory Team (NVT)
Department of Biomedical Technology, nám. Sítná 3105, Kladno, 272 01
prof. Ing. Karel Roubík, Ph.D.
Who we are?
We are a team of experts interested in mechanical lung ventilation and various aspects of technology for anesthesia, resuscitation and critical care medicine. Prof. Karel Roubik, Ph.D., is a leader of the team. Team’s members and their CVs are available at www.ventilation.cz.
What research do we do?
The main scope of our team is research, design and application of novel techniques for treatment of acute and chronical respiratory insufficiency in neonates, children and adults. We deal with high frequency ventilation, development of Demand Flow System, application of HeliOx in respiratory care and other topics. We also deal with monitoring not only in respiratory care, but also in other areas of anesthesiology and critical care medicine. Our specialty is also clinical research, including investigation of gas exchange limitations in victims covered with avalanche snow.
What are we specifically working on?
Results of our work are presented at www.ventilation.cz in the “publications” section.
S kým spolupracujeme?
During research, we cooperate with:
- Department of Anesthesiology and Critical Care Medicine, FNKV, 3rd Faculty of Medicine, UK in Prague
- Department of Anesthesiology and Critical Care Medicine, Faculty Military Hospital, 1st Faculty of Medicine, UK in Prague
- Department of Anesthesia and Resuscitation, Thomayer Hospital in Prague
- VU University Medical Center in Amsterdam (NL, EU)
- CareFusion, Yorba Linda, California, USA
- Economedtrx, Lake Arrowhead, California, USA
- CleanAir, Jablonec n. Nisou
- and many other partners
Selected publications are listed and their full texts are provided at www.ventilation.cz in “publications” section.
Rehabilitation process quantification#rpq
Department of Information and Communication Technologies in Medicine, Studničkova 7/2028 Prague 2
Team / project name
Rehabilitation process quantification
Who we are?
Ondřej Antoš, Karel Hána, Markéta Janatová, Jaroslav Jeřábek, Jan Kašpar, Vojtěch Malina, Jan Mužík, Kateřina Pilátová, Pavel Smrčka, Luisa Šedivcová
What research are we doing?
We are interested in monitoring and quantifying the process of rehabilitation care of patients with focal brain injury, using elements of virtual reality, mobile applications and telemedicine systems. We are focused on technologies for the rehabilitation of patients with balance disorders or other related difficulties.
What is it for?
The goal of all rehabilitation procedures is to improve the patient's functional abilities. A number of rehabilitation procedures lead to this goal, which work with the patient in the given environment of the rehabilitation ambulance, or with the help of distant therapy, when the patient rehabilitates in the home environment. The aim of all procedures is to improve the quality of life of patients. Rehabilitation, especially in the initial stages, represents a relatively large burden for a target person, which can significantly affect the functionality of the cardiovascular system and when a certain limit of exercise tolerance is exceeded, rehabilitation may slow down or worsen. That is why we deal with technologies, telemedicine systems and procedures that support the process of distant care.
What exactly are we working on
The issues we are dealing with can be divided into three main areas:
1. Monitoring of a rehabilitating patient in terms of his physical activities and the response of the cardiovascular systém
This part takes place in close cooperation with the Department of Rehabilitation Medicine, First Faculty of Medicine, Charles University and the General Hospital, which admits patients after brain damage to the program of the so-called day hospital, where they are rehabilitated for 3 weeks. At present, it is not objectified how much time they spend exercising, how they burden the affected and healthy limbs and how much stress the cardiovascular system occurs in rehabilitated patients.
The goal is:
- to obtain an overview of the physical activities of patients rehabilitated within the day hospital, on the basis of this overview it will be possible to optimize the daily regime of patients
- using HRV analysis to determine the degree of stress and cardiovascular load in general in individual phases of rehabilitation
- The analysis of the movement of the affected limb, respectively the improvement of its use during rehabilitation, should provide essential information. Improving movement, ie the gradual involvement of the affected limb in physical activities, is proof of the success of the rehabilitation. Recording of gradual improvement of limb movement resp. limbs would be a measurable and objective record of a better patient. Based on these data, it would then be possible to optimize the rehabilitation procedure.
Based on this information and the experience gained, another goal should be fulfilled in the next phase - monitoring the success of the rehabilitation process carried out in the home environment. From a purely technical point of view, this would be the design and construction of a device enabling the above-mentioned measurements to be carried out during rehabilitation carried out at home. On the one hand, this technical equipment would bring very valuable information about physical activities, time and duration of exercise, the quantitative parameters of which it would be able to continuously monitor.
2. Use of virtual reality for rehabilitation of patients with balance disorders
Balance is ensured in the organism by the interaction of three sensory inputs: visual, vestibular and proprioceptive. Therefore, imbalances can occur when individual systems or centers fail, which fold for their mutual coordination. The standard procedure in the rehabilitation of balance disorders is the use of biological feedback, which uses a stabilometric platform on which the patient stands and monitors the movement of his center of gravity on the screen.
The department participates in research and development of new medical devices in the field of rehabilitation. The developed medical devices include, for example, a patient device consisting of a stabilometric platform, a wrist pedometer and a tablet with a program containing therapeutic games.
Telemedicine expansion can allow remote configuration of a therapeutic exercise plan and remote recording of the course and results of therapy. The therapy also includes a web environment for the management of distance therapy and evaluation of health improvement. Developed medical devices are intended for therapy and comparative evaluation of patients with motor and cognitive impairments due to congenital or acquired brain damage, in geriatric patients, and other patient groups with the need to improve stability and support balance and cognitive training.
The results of the research are used by patients of various rehabilitation institutions after injuries or surgical procedures of the musculoskeletal and nervous system. Specialists, general practitioners, physiotherapists or other specialists in hospitals, nursing homes or spas.
Users can be clinics, dispensaries and their clients undergoing rehabilitation for various reasons, where nursing staff will appreciate technological advances in care, electronic procedures and support for home therapy provided remotely. It will improve the quality of care and increase the quality of life of patients suffering from a variety of disabilities, including increasing the comfort of life for their families.
3. Telerehabilitation and patient studies
The university workplace is a professional guarantor and implementer of scientific and technological activities that provide tools, methods and a support system for the implementation of user / patient studies in the field of rehabilitation and telemedicine. The department provides patient research in the form of identification of user needs, determination of requirements for therapeutic / exercise plans and carries out the actual implementation of the pilot deployment of telerehabilitation technology, including the validation of follow-up processes.
Who funds our research
- Research projects
- Resources from specific research - cooperation with students
- Joint workplace of biomedical engineering FBMI and 1.LF UK in Prague FBMI CTU in Prague
- 1st Faculty of Medicine, Charles University in Prague
- Thanks to the support of CleverTech s.r.o., spin-off company FBMI and 1.LF UK in Prague.
Who we work with
- Department of Rehabilitation Medicine, First Faculty of Medicine, Charles University and General Hospital
- Department of Neurology, First Faculty of Medicine, Charles University and General Hospital in Prague
- Department of Neurology for Adults, 2nd Faculty of Medicine and Motol University Hospital
- CleverTech s.r.o., spin-off company FBMI CTU and 1.LF UK in Prague
- HomeBalance s.r.o., spin-off company 1.LF UK in Prague
- ARTAK, Czech Association of Robotics Telemedicine and Cybernetics
- Rehabilitation Institute Kladruby
- Hana, K., Kaspar, J., Kucera, L., Muzik, J., Smrcka, P., Vesely, T., Viteznik, M.: Method of wireless connection of an intelligent house with a rescue system patrol and a system for its implementation. Patent 308531, 16.9.2020, Industrial Property Office in Czech Republic, 2020
- Hana, K., Kaspar, J., Kucera, L., Muzik, J., Smrcka, P., Vesely, T., Viteznik, M., Kliment, R.: Monitoring and transport system especially for the transport of infectious patients. Patent 307932, 17.7.2019, Industrial Property Office in Czech Republic, 2019
- Hana, K., Kaspar, J., Kucera L., Muzik, J., Smrcka, P., Vesely, T., Viteznik, M.: Surveillance equipment for monitoring persons, especially in difficult conditions, and a system for placing sensors on the human body. Patent 307930, 17.7.2019, Industrial Property Office in Czech Republic, 2019
- Hlavinka, P., Sebelka, Z., Hana, K., Kaspar, J., Muzik, J., Smrcka, P.: Method of three-stage communication of the notification center and the end element of the warning. Patent 307931, 17.7.2019, Industrial Property Office in Czech Republic, 2019
- Muzik, J., Viteznik, M., Hana, K., Smrcka, P., Kaspar, J., Funda, T., Kudlicka, J., Mlcek, M., Streda, L.: Low energy defibrillation equipment. Patent 306991, 20.9.2017, Industrial Property Office in Czech Republic, 2017
- Kaspar, J.; Hon, Z.; Janatova, M.; Smrcka, P.; Viteznik, M.; Hana, K.; Vesely T.; Muzik, J.: Biotelemetric system to support monitoring of the psychophysiological state of man. Patent 306895, 19.7.2017, Industrial Property Office in Czech Republic, 2017
- Janatova, M.; Ticha, M.; Hana, K.; Svestkova, O.: Use of force platform and visual feedback in home-based therapy of patients with brain injury. In: Brain Injury, vol. 31, Issue 6-7, 2017, ISSN: 0269-9052, IF1,97 (2016)
- Team of Biomechanics and Assistive Technology
doc. Ing. Patrik Kutilek, M.Sc., Ph.D.
We are a multidisciplinary team dedicated primarily to, but not limited to, research in biomechanics and assistive technologies. Above all, we focus on the study of kinematics and dynamics of motion and physiological data, and the design of electronic and mechatronics systems designed to measure and evaluate the movement and physiological data of humans and animals. We are also engaged in ergonomic and the development and testing of mechanical elements of medical devices, especially assistive devices. We take advantage of the fact that specialists with knowledge of robotics, informatics and medicine, with experience in the fields of simulations, measurement, processing and analysis of mechanical, physical data, met at the FBME CTU.
We develop methods and systems for recording and evaluating motion and physiological data, developing methods and systems for recording and evaluating force and moment effects, designing mechanical parts of assistive devices, developing medical software for assistive devices.
doc. Ing. Patrik Kutílek, M.Sc., Ph.D.; Ing. Ana Carolina DAngeles; Bc. Jan Hýbl; Ing. et Ing. Jan Hejda, Pd.D.; Mgr. Slávka Vítečková; Ing. Petr Volf; etc.
- Kliment, R., Smrčka, P., Hána, K., Schlenker, J., Socha, V., Socha, L., Kutílek, P.; Wearable modular telemetry system for the integrated rescue system operational use (2017) Journal of Sensors, 2017, art. no. 9034253.
- Kutilek, P., Mares, J., Hybl, J., Socha, V., Schlenker, J., Stefek, A.; Myoelectric arm using artificial neural networks to reduce cognitive load of the user (2017) Neural Computing and Applications, 28 (2), pp. 419-427.
- Svoboda, Z., Janura, M., Kutilek, P., Janurova, E.; Relationships between movements of the lower limb joints and the pelvis in open and closed kinematic chains during a gait cycle (2016) Journal of Human Kinetics, 50 (2), pp. 37-43.
- Schlenker, J., Socha, V., Riedlbauchová, L., Nedělka, T., Schlenker, A., Potočková, V., Malá, Š., Kutílek, P.; Recurrence plot of heart rate variability signal in patients with vasovagal syncopes (2016) Biomedical Signal Processing and Control, 25, pp. 1-11.
- Kutilek, P., Cakrt, O., Socha, V., Hana, K.; Volume of confidence ellipsoid: A technique for quantifying trunk sway during stance (2015) Biomedizinische Technik, 60 (2), pp. 171-176.
- Hejda, J., Cakrt, O., Socha, V., Schlenker, J., Kutilek, P.;3-D trajectory of body sway angles: A technique for quantifying postural stability (2015) Biocybernetics and Biomedical Engineering, 35 (3), art. no. 72, pp. 185-191.
- Kutilek, P., Socha, V., Viteckova, S., Svoboda, Z.; Quantification of gait asymmetry in patients with ankle foot orthoses based on hip-hip cyclograms (2014) Biocybernetics and Biomedical Engineering, 34 (1), pp. 46-52.
- Bizovska, L., Svoboda, Z., Kutilek, P., Janura, M., Gaba, A., Kovacikova, Z.; Variability of centre of pressure movement during gait in young and middle-aged women (2014) Gait and Posture, 40 (3), pp. 399-402.
- Viteckova, S., Kutilek, P., Jirina, M.; Wearable lower limb robotics: A review (2013) Biocybernetics and Biomedical Engineering, 33 (2), pp. 96-105.
- Kutilek, P., Viteckova, S., Svoboda, Z., Smrcka, P.; Kinematic quantification of gait asymmetry in patients with peroneal nerve palsy based on bilateral cyclograms (2013) Journal of Musculoskeletal Neuronal Interactions, 13 (2), pp. 244-250.
- Hejda, J., Kutilek, P., Hozman, J., Cerny, R.; Motion capture camera system for measurement of head and shoulders position (2012) Biomedizinische Technik, 57 (SUPPL. 1 TRACK-B), pp. 472-475.
- Mikšovský, J., Kutílek, P., Lukeš, J., Tolde, Z., Remsa, J., Kocourek, T., Uherek, F., Jelínek, M.; Adhesion properties of DLC and TiO<inf>2</inf> thin films using scratch test methods (2011) Chemicke Listy, 105 (17).
- Telemedicina and diabetes#td
Department of Information and Communication Technologies in Medicine
Studničkova 7/2028 Praha 2
Ing. Jan Mužík, Ph.D.
Who we are?
Multidiscplinary team consisting of experts from FBMI CTU, 1st and 2nd Faculty of Medicine and CIIRK CTU
Jan Mužík, Ann Holubová, Jan Brož, Dominik Fiala, Marek Doksanský, David Gillar, Tomáš Kučera, Tomáš Kuttler, Jan Kašpar, Pavel Smrčka, Karel Hána, Miroslav Mužný, Martina Vlasáková, Ondřej Pelák, Klára Bajerová, Patrícia Štefanová
What research do we do?
We focus mainly on the design of telemedicine systems used to monitor and support the treatment of chronically ill patients (esp. Patients with diabetes mellitus, hypertension and cardiovascular diseases), to support and motivate movement in hemiparetic patients and patients with mental illnesses, and last but not least prevention of associated diseases.
These systems include especially applications for smartphones, wearable electronics and mobile medical devices, smart scales, pressure gauges, etc. Emphasis is placed on wireless communication and automatic data collection.
Current projects and clinical studies:
Diani telemedicine system (http://www.albertov.cz/projekty/diani/) for support of patients with diabetes
- Diani web application development (https://www.diani.cz/)
- development of a mobile application of the Diabetesdagboka diabetic diary
- Development of other android applications focused on self-management of diabetes and serious games
- Development of a telecommunications system for families with diabetic children
- Online monitoring and data collection in patients with DM1 and DM2
- collection and analysis of data from wearable electronics and medical devices (glucometers, CGM, insulin pumps, pressure gauges, scales, pedometers, etc.)
- Telemedicine system for patients with hypertension and cardiovascular disease (arrhythmia)
- Online monitoring and data collection in patients with hypertension and cardiovascular disease
- ollection and analysis of data from medical devices (pressure gauges with support for the detection of cardiac abnormalities) + support for the recording of other medical information
- SOMA: Physical Health Care Project and Training for Independent Living Abilities
- Emed Telemedicine system for Bohnice Psychiatric Hospital
- monitoring of physical activity in schizophrenic patients to support their health and prevent the development of associated diseases or suppress their development
- connection of the system to NIS (Hippo)
- Faculty Hospital Motol:
- Influence of telemedicine system on the quality of life of patients with type 1 diabetes mellitus
- Influence of physical activity and other parameters on diabetes mellitus compensation - possibilities of telemonitoring and computer data processing within expert system
- Rehabilitation Center Kladruby:
- Influence of the involvement of hemiparetic patients on pedometer accuracy and possibilities of their use for long-term monitoring
Results of our work:
- mobile application for smartphones Diabetesdagboka (in cooperation with NSE, Norway)
- diabetic log for recording blood glucose values, injected insulin doses,carbohydrates consumed, and physical activity (https://play.google.com/store/apps/details?id=no.telemed.diabetesdiary)
- Diabetesdagboka app for smartwatches Pebble Now (in collaboration with NSE, Norway)
- automatic transfer of records entered through the watch into the application
- Diani web application (https://www.diani.cz/)
- collection, analysis and online monitoring of measured parameters in patients with DM
- automatic synchronization of records from the Diabetesdagboka mobile app
- displaying data from continuous glucose monitors, activity trackers, smart scales, pressure gauges, insulin pumps
- diabetic watch application for AndroidWear
- automatic transmission and display of blood glucose values measured by personal meter
- display data in the form of spiral graphs
- a tool for identifying glycemic excursions at a certain stage of the day and increasing adherence to regular glycemic control
- SOMA web application
- ollection and online monitoring of physical activity records in patients with mental illness
Who we cooperate with?
- Internal clinics of 2nd Medical Faculty UK and Faculty Hospital Motol
- Norwegian Centre for E-health Research, Tromso(https://ehealthresearch.no/en/)
- University of Tromsø The Arctic University of Norway (https://en.uit.no/startsida)
- University of Applied Sciences | Technikum Wien
- Analysis of Dagboka application tracking and frequency tracking data used by DM1 patients
- Design and implementation of Dagboka application changes according to human typology using data from personality questionnaire and application using DM1 patients
- Interactive toys for children as a tool for barrier-free communication between a child with pre-school DM1 and a parent
- Design and implementation of glycemic watches using spiral graphs
- Relationship between heart rate and actual blood glucose levels during sleep and the possibility of using continuous heart rate monitoring as a tool for early detection of hypoglycemia
- Possibilities of using surveillance system and online monitoring of selected parameters in patients with chronic illness who live alone
- The complete list can be found on the Albertov website (http://www.albertov.cz/studentske-projekty/)
Nanocomposite and nanocrystalline materials for implantology and biomedicine#pld
Department of natural sciences, nám. Sítná 3105, Kladno, 27201 Ing. Petr Písařík, Ph.D. ORCID Ing. Tomáš Kocourek, Ph.D. ORCID Ing. Jan Mikšovský, Ph.D. ORCID Ing. Jan Remsa, Ph.D. ORCID
Topics of interest
Fabrication and study of thin layers of materials for implantology, tissue engineering and medicine. We fabricate and study thin layers of biocompatible materials, namely:
- Hydroxyapatite for better osseointegration of implants (tooth, hip replacement)
- Diamond-like-carbon for better biocompatibility (minimization of immune response a friction) implants such as joint replacement, arterial stents, heart valves
- Titanium dioxide for photocatalytic and antibacterial applications for medical equipment (for example: urethral catheter)
- Silver for antibacterial applications on implants
- Organic and polymer materials (MAPLE technology) for sensors and tissue engineering
- Bioglass, zircon, doped biocompatible layers (Ag, Mo, Cr, Ti …), nanocrystalline and nanocomposite layers, atd.
The goal is to develop new types biocompatible thin layers for application in medicine and sensor fields.
Modification of implant surface
We modify the surface of implant materials via mechanical, laser, and plasma (O2, NH2, O3) treatment for better biocompatibility. Resulting surfaces are studied with emphasis on support or inhibition of different cell growth.
Interaction study of UV laser irradiation with material
Interaction process of laser irradiation with material (biological tissue) is studied with thermocamera, fast infrared detectors, optically and spectroscopically. Damage or modification of tissue is evaluated in cooperation with medical faculties.
Preparation of nanoparticles of metals and silicon
We synthetize nanoparticles via pulsed laser ablation in liquid for drug delivery systems and biomolecular tagging.
Most of our work take place in the Laboratory of excimer laser in the building of Institute of Physics of the Czech Academy of Sciences (Na Slovance 1999/2, 182 21 Prague 8) and laboratories at the Department of Natural Sciences at FBME CTU (sq. Sítná 3105, 272 01 Kladno).
Laboratory of excimer laser belongs to the Institute of Physics of the Czech Academy of Sciences, Department of optical and biophysical systems and Department of Natural Sciences FBMI CTU participates in this department by loaning equipment, cooperation of persons and measuring and evaluating results in laboratories at FBMI.
- KrF a ArF excimer laser Compex 205F for layers fabrication via pulsed laser deposition
- Contact angle measurement system Krüss DS 100 for determination of wetting and surface energy
- Atomic Force MicroscopeSolver Next (NT- MDT) for measuring of topography, elastic properties, adhesion microhardness
- Fourier Transform InfraRed Spectrometer (Nicolet 6700) for chemical analysis of layers and materials (gases, liquids, solids)
- Rapid Thermal Annealing device - Solaris 75 (Surface Science Integration) for prepared layers modification (recrystallization)
- Profilometer Alphastep IQ (KIA Tencor) for thickness and roughness measurement
- UV-VIS fibre spectrometer USB2000+ (Ocean optics) with range of 200-900 nm for spectrophotometric (transmittance, reflectance) and fluorescent measurement, including suprasil cuvette for UVrange and integration sphere for measurement of diffusion surfaces
- UV-VIS spectrophotometer UV-2600 (Shimadzu) - The compact UV-2600 is a universal, research-grade spectrophotometer that can be used in a wide range of fields, and easily expanded to suit the measurement objective. By using the optional integrating sphere, the measurement wavelength range of the UV-2600 can be extended to the near-infrared region of 1400 nm.
- Thermocamera FLUKE Ti-55 for heat transfer study in material and biological tissues
- Vacuum interaction chambers for laser deposition and hybrid laser deposition (combination of RF discharge, magnetron a laser deposition)
- Magnetron sputtering system Kurt Lesker;
- Ion source Kaufman-Robinson EH200 with maximum energy of 210 eV
- UV irradiation sources (germicide, forensic (Spectroline Optimax OPX-365UV), and for photocatalysis), power meters in UV range: Hamamatsu H9535 with maximum at 250 nm and International Light Technology ILT-1700 with maximum at 365 nm
- Tribometr with corrosion and wear properties measurement extension (Anton Paar Tribometr with rotation and linear testing including liquid environment testing, and potentiostat VersaSTAT3)
- Digital Microscope VHX-7000 (Keyence) - 2D/3D measuring, 4K Ultra-High Accuracy, Change magnification between 20x to 6000x.
- Original Prusa i3 MK3S (Prusa) – possibility to print 3D objects from materials PLA, ABS, PET a Flex PP
- Chemical workplace:
- Fume chamber, centrifuge, laboratory scale
- Reverse osmotic device for clean water RiOs-DI 3 UV (Millipore) with resistance > 10 M·cm,
- Devices for measurement of liquid pH (Inolab 730)
- Ceramic oven up to 1100 °C
- Magnetic mixer with heater, mixer with upper stirring
- Oscilloscopes, energy meters for lasers, He-Ne lasers, optical microscope, etc.
- Dry air source
- Optical tables Standa including equipment for needed for construction of optical lines and samples manipulation (Thorlab)
Projects from grant agencies (GAČR, TAČR) and Student grant competition (SGS CVUT CZ).
Exchange program ERASMUS+ with the University of Kassel, Germany – valid for students and employees.
Firms: BEZNOSKA s.r.o., ProSpon spol. s r.o., Lasak s.r.o., Ippon s.r.o.
Institutes: Institute of Physics of the Czech Academy of Sciences, Institute of Physiology of the Academy of Sciences of the Czech Republic
Scientific outputs of our laboratory:
- TYUNINA, M., RUSEVICH, L. L., KOTOMIN, E. A., PACHEROVA, O., KOCOUREK, T., DEJNEKA, A. Epitaxial growth of perovskite oxide films facilitated by oxygen vacancies, J. Mater. Chem. C 2021, 1, 1. DOI: 10.1039/d0tc05750a.
- ZEMEK, J., HOUDKOVA, J., JIRICEK, P., JELINEK, M., JUREK, K., KOCOUREK, T., LEDINSKY, M. In-depth distribution of elements and chemical bonds in the surface region of calcium-doped diamond-like carbon films. Appl. Surf. Sci. 2021, 539, 148250(9). DOI: 10.1016/j.apsusc.2020.148250
- REMSA, J., PÍSAŘÍK, P., DEJNEKA, A., CHRZANOWSKI, A., LÁT, J., KURKIN, O. Coating especially for cooling system surfaces (2020) - Patent no.: 34 486
- ŠKUBNÍKOVÁ, A., PÍSAŘÍK, P.: Tribological properties of contact lenses. In: Instruments and Methods for Biology and Medicine 2020. Praha: Czech Technical University in Prague, 2020. p. 61-64. ISBN 9788001067963.
- KOŠINOVÁ, L., PÍSAŘÍK, P., TOLDE, Z., BRAJER, J., KAUFMAN, J.: Improving properties of titanium alloy used for modern hip prosthesis. In: Instruments and Methods for Biology and Medicine 2020. Praha: Czech Technical University in Prague, 2020. p. 40-43. ISBN 9788001067963.
- TYUNINA, M., PACHEROVA, O., NEPOMNIASHCHAIA, N., VETOKHINA, V., CICHON, S., KOCOUREK, T., DEJNEKA, A. In situ anion-doped epitaxial strontium titanate films. Phys. Chem. Chem. Phys. 2000, 22, 24796(9). DOI: 10.1039/d0cp03644g.
- TYUNINA, M., PERÄNTIE, J., KOCOUREK, T., SAUKKO, S., JANTUNEN, H., JELINEK, M., DEJNEKA, A. Oxygen vacancy dipoles in strained epitaxial BaTiO3 films. Phys. Rev. Res. 2020, 2, 023056(8). DOI: 10.1103/PhysRevResearch.2.023056.
- TYUNINA, M., VETOKHINA, O., NEPOMNIASHCHAIA, N., PACHEROVA, O., CICHON, S., KOCOUREK, T., JELINEK, M., DEJNEKA, A. Multiple optical impacts of anion doping in epitaxial barium titanate films. APL Mat. 2020, 8, 071107(6). DOI: 10.1063/5.0007209.
- JELINEK, M., KOCOUREK, T., JUREK, K., JELINEK, M., SMOLKOVÁ, B., UZHYTCHAK, M., LUNOV, O. Preliminary Study of Ge-DLC Nanocomposite Biomaterials Prepared by Laser Codeposition. Nanomaterials 2019, 9(3), 451(15). DOI: 10.3390/nano9030451.
- PERÄNTIE, J., SAVINOV, M., KOCOUREK, T., JELÍNEK, M., JANTUNEN, H., DEJNEKA, A., TYUNINA, M. Hybrid polar state in epitaxial (111) PbSc0.5Nb0.5O3 relaxor ferroelectric films. Phys. Rev. Mater. 2019, 3, 014403(7). DOI: PhysRevMaterials.3.014403.
- PÍSAŘÍK, P., REMSA, J., MIKŠOVSKÝ, J. Improving the properties of spectacle lenses with a diamond-like carbon, Jemná mechanika a optika 11-12 (2019) 338 - 391.
- REMSA, J., PÍSAŘÍK, P., DEJNEKA, A., CHRZANOWSKI, A., LÁT, J. Coating especially for cooling system surfaces (2019) - Patent no.: 33 538
- STUPAKOV, A., PACHEROVA, O., KOCOUREK, T., JELINEK, M., DEJNEKA, A., TYUNINA, M. Negative magnetoresistance in epitaxial films of neodymium nickelate. Phys. Rev. B 2019, 99, 08511(7). DOI: 10.1103/PhysRevB.99.085111.
- PÍSAŘÍK, P., J. REMSA a J. MIKŠOVSKÝ. Zlepšení vlastností brýlových čoček pomocí diamantu podobného uhlíku. Jemná mechanika a optika. 2019, 2019(11-12), 388-391. ISSN 0447-6441.
- JELÍNEK, M. et al. Preliminary Study of Ge-DLC Nanocomposite Biomaterials Prepared by Laser Codeposition. Nanomaterials. 2019, 9(3), 1-15. ISSN 2079-4991. DOI: 10.3390/nano9030451.
- ZEMEK, J. et al. Surface and in-depth distribution of sp(2) and sp(3) coordinated carbon atoms in diamondlike carbon films modified by argon ion beam bombardment during growth. Carbon. 2018, 134 71-79. ISSN 0008-6223. DOI: 10.1016/j.carbon.2018.03.072.
- JELÍNEK, M. et al. Laser-synthesized nanocrystalline, ferroelectric, bioactive BaTiO3/Pt/FS for bone implants. JOURNAL OF BIOMATERIALS APPLICATIONS. 2018, 32(10), 1464-1475. ISSN 0885-3282. DOI: 10.1177/0885328218768646.
- KOCOUREK, T. et al. Crystalline Thin Layers of BaTiO3 for Gas Sensors Prepared by PLD. In: Advanced Nanotechnologies for Detection and Defence against CBRN Agents. Springer Nature, 2018. s. 17-30. ISSN 1874-6500. ISBN 978-94-024-1516-2. DOI: 10.1007/978-94-024-1298-7_2.
- PÍSAŘÍK, P. et al. Antibacterial coatings for biomedical applications. In: Advanced Nanotechnologies for Detection and Defence against CBRN Agents. Springer Nature, 2018. s. 467-476. ISSN 1874-6500. ISBN 978-94-024-1516-2. DOI: 10.1007/978-94-024-1298-7_46.
- SEKYRKA, O., M. JELÍNEK a J. REMSA. Study of improvement of implants coating with focus on doped biomaterials and laser deposition. In: INSTRUMENTS AND METHODS FOR BIOLOGY AND MEDICINE 2018 Conference Proceedings. Instruments and methods for biology and medicine (IMBM 2018), Kladno, 2018-05-10. Prague: Czech Technical University, 2018. s. 49-52. ISBN 978-80-01-06502-0.
- KONDRATIEVOVÁ, J., M. JELÍNEK a T. KOCOUREK. Improvement of DLC implant coating using hybrid laser technology and germanium dopation. In: INSTRUMENTS AND METHODS FOR BIOLOGY AND MEDICINE 2018 Conference Proceedings. Instruments and methods for biology and medicine (IMBM 2018), Kladno, 2018-05-10. Prague: Czech Technical University, 2018. s. 33-36. ISBN 978-80-01-06502-0.
- URZOVÁ, J. a M. JELÍNEK. Determining ablation depth and ablation threshold for tissue using CT imaging. In: INSTRUMENTS AND METHODS FOR BIOLOGY AND MEDICINE 2018 Conference Proceedings. Instruments and methods for biology and medicine (IMBM 2018), Kladno, 2018-05-10. Prague: Czech Technical University, 2018. s. 68-71. ISBN 978-80-01-06502-0.
- JELÍNEK, M. et al. Technologie výroby hydroxyapatitových kompozitů pomocí pulzní laserové depozice využívající pevnolátkový Nd:YAG laser. [Functional Sample] 2018.
- PÍSAŘÍK, P., et al. Diamond-like carbon prepared by pulsed laser deposition with ion bombardment: physical properties. Applied Physics A: Materials Science & Processing. 2018, 124(1), s. 1-9. ISSN 1432-0630. DOI: 10.1007/s00339-017-1501-5.
- ZEMEK, J., et al. Amorphous carbon nanocomposite films doped by titanium: Surface and sub-surface composition and bonding. Diamond and Related Materials. 2018, 81s. 61-69. ISSN 0925-9635. DOI: 10.1016/j.diamond.2017.11.009.
- URZOVÁ, J. a JELÍNEK, M. Heat transfer modelling of pulsed laser-tissue interaction. Laser Physics. 2018, 28(3), s. 1-5. ISSN 1054-660X. DOI: 10.1088/1555-6611/aa9a9a.
- JELÍNEK, M., et al. Doped and Multilayer Biocompatible Materials Prepared by Hybrid Laser Deposition. International Journal of Bioscience, Biochemistry and Bioinformatics. 2018, 8(4), s. 252-258. ISSN 2010-3638. DOI: 10.17706/ijbbb.2018.8.4.252-258.
- PÍSAŘÍK, P., et al. Antibacterial, mechanical and surface properties of Ag-DLC films prepared by dual PLD for medical applications. Materials Science and Engineering C. 2017, 77, pp. 955-962. ISSN 0928-4931. DOI: 10.1016/j.msec.2017.04.005.
- FILOVA, E., et al. Adhesion and differentiation of Saos-2 osteoblast-like cells on chromium-doped diamond-like carbon coatings. Journal of Materials Science: Materials in Medicine. 2017, 28(17), pp. 1-14. ISSN 0957-4530. DOI: 10.1007/s10856-016-5830-2.
- JELÍNEK, M., et al. PLD prepared bioactive BaTiO3 films on TiNb implants. Materials Science and Engineering C, Biomimetic and Supramolecular Systems. 2017, 70, pp. 334-339. ISSN 0928-4931. DOI: 10.1016/j.msec.2016.08.072.
- KOCOUREK, T., et al. Diamond-like carbon layers modified by ion bombardment during growth and researched by Resonant Ultrasound Spectroscopy. Applied Surface Science. 2016, In press. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2017.03.274.
- JELÍNEK, M., et al. Hybrid laser technology and doped biomaterials. Applied Surface Science. 2016, In press. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2017.03.103.
- ZEIPL, R., et al. Scanning thermal microscopy of Bi2Te3 and Yb0.19Co4Sb12 thermoelectric films. Applied Physics A: Materials Science and Processing. 2016, 122:155. ISSN 0947-8396. DOI: 10.1007/s00339-016-0017-8.
- JELÍNEK, M., et al. Thermoelectric nanocrystalline YbCoSb laser prepared layers. Applied Physics A: Materials Science and Processing. 2016, 122:478. ISSN 0947-8396. DOI: 10.1007/s00339-016-9685-7.
- REMSA, J., et al. Very Smooth FeSb2Te and Ce0.1Fe0.7Co3.3Sb12 Layers Prepared by Modified PLD. Journal of Electronic Materials. 2016, 45(3), pp. 1921-1926. ISSN 0361-5235. DOI: 10.1007/s11664-015-4295-2.
- JELÍNEK, M., et al. Bonding and bio-properties of hybrid laser/magnetron Cr-enriched. Materials Science and Engineering C, Biomimetic and Supramolecular Systems. 2016, 58(58), pp. 1217-1224. ISSN 0928-4931. DOI: 10.1016/j.msec.2015.09.006.
- JELÍNEK, M., et al. Dual laser deposition of Ti:DLC composite for implants. Laser Physics. 2016, 26pp. 1-8. ISSN 1054-660X. 10.1088/1054-660X/26/10/105605.
- JELÍNEK, M., et al. Thermoelectric Simple and Multilayers Prepared by Laser. Journal of Materials Science and Chemical Engineering. 2016, 4(1), pp. 52-64. ISSN 2327-6053.
- JELÍNEK, M., et al. Hybrid Laser Technology for Creation of Doped Biomedical Layers. Journal of Materials Science and Chemical Engineering. 2016, 4(1), pp. 98-104. ISSN 2327-6053. DOI: 10.4236/msce.2016.41014.
- ZEIPL, R., et al. Physical Properties of Bi2Te3 Nanolayers. NATO Science for Peace and Security Series A: Chemistry and Biology. 2015, 39pp. 325-331. ISSN 1874-6489. DOI: 10.1007/978-94-017-9697-2_33.
- JELÍNEK, M., et al. Chromium-doped DLC for implants prepared by laser-magnetron deposition. Materials Science and Engineering C, Biomimetic and Supramolecular Systems. 2015, 46(1.1.2015), pp. 381-386. ISSN 0928-4931. DOI: 10.1016/j.msec.2014.10.035.
- PÍSAŘÍK, P., et al. Influence of diamond and graphite bonds on mechanical properties of DLC thin films. In: Journal of Physics Conference Series. 7th International Workshop on Decoherence, Information, Complexity and Entropy (DICE) - Spacetime - Matter - Quantum Mechanics. Castiglioncello, 15.09.2014 - 19.09.2014. Bristol: IOP Publishing Ltd. 2015, pp. 1-6. ISSN 1742-6588. DOI: 10.1088/1742-6596/594/1/012008.
- PÍSAŘÍK, P., et al. Chromium doped diamond like carbon films deposited by dual pulsed laser deposition. Applied Physics A: Materials Science and Processing. 2014, 117(1), pp. 83-88. ISSN 0947-8396. DOI: 10.1007/s00339-013-8206-1.
- JELÍNEK, M., et al. Preliminary comparative study of laser-prepared DLC and Cr-doped DLC for bacteria adhesion. Applied Physics A: Materials Science and Processing. 2014, 116(3), pp. 1437-1443. ISSN 0947-8396. DOI: 10.1007/s00339-014-8256-z.
- SOCOL, M., et al. Organic heterostructures based on arylenevinylene oligomers deposited by MAPLE. Applied Surface Science. 2014, 302(0), pp. 216-222. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2013.12.091.
- MIKŠOVSKÝ, J., et al. Cell adhesion and growth on ultrananocrystalline diamond and diamond-like carbon films after different surface modifications. Applied Surface Science. 2014, 297pp. 95-102. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2014.01.085.
- ZEZULOVÁ, M., et al. Polycrystalline LiNbO3 thin films characterized by infrared and Raman spectroscopy. Laser Physics. 2014, 24(2), pp. 1-4. ISSN 1054-660X. DOI: 10.1088/1054-660X/24/2/025701.
- KOCOUREK, T., et al. Silver doped metal layers for medical applications. Laser Physics. 2014, 24(8), pp. 1-7. ISSN 1054-660X. 10.1088/1054-660X/24/8/085602.
- KOCOUREK, T., et al. Silver doped metal layers for medical applications. In: Journal of Physics: Conference Series, vol. 497. 22nd International Laser Physics. Prague, 15.07.2013 - 19.07.2013. Bristol: IOP Publishing Ltd. 2014, pp. 1-9. ISSN 1742-6588. DOI: 10.1088/1742-6596/497/1/012021.
- KYMPLOVÁ, J., et al. Assessment of the Suitability of Excimer Lasers in Treating Onychomycosis. In: Journal of Physics: Conference Series, vol. 497. 22nd International Laser Physics. Prague, 15.07.2013 - 19.07.2013. Bristol: IOP Publishing Ltd. 2014, pp. 1-13. ISSN 1742-6588. DOI: 10.1088/1742-6596/497/1/012022.
- ZEIPL, R., et al. Properties of thermoelectric Ce0.09Fe0.67Co 3.33Sb12/FeSb2Te multi-layered structures prepared by laser ablation. In: Journal of Physics: Conference Series, vol. 497. 22nd International Laser Physics. Prague, 15.07.2013 - 19.07.2013. Bristol: IOP Publishing Ltd. 2014, pp. 1-10. ISSN 1742-6588. 10.1088/1742-6596/497/1/012038.
- JELÍNEK, M., et al. Comparison of the surface properties of DLC and ultrananocrystalline diamond films with respect to their bio-applications. PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE. 2013, 210(10), pp. 2106-2110. ISSN 1862-6300. DOI: 10.1002/pssa.201228713.
- JELÍNEK, M., et al. Composition, XRD and morphology study of laser prepared LiNbO3 films. Applied Physics A: Materials Science and Processing. 2013, 110(4), pp. 883-888. ISSN 0947-8396. DOI: 10.1007/s00339-012-7191-0.
- JELÍNEK, M., et al. Influence of ion bombardment on growth and properties of PLD created DLC films. Applied Physics A: Materials Science and Processing. 2013, 110(4), pp. 943-947. ISSN 0947-8396. DOI: 10.1007/s00339-012-7215-9.
- PÍSAŘÍK, P., et al. Study of optical properties and biocompatibility of DLC films characterized by sp3 bonds. Applied Physics A: Materials Science and Processing. 2013, 112(1), pp. 143-148. ISSN 0947-8396. DOI: 10.1007/s00339-012-7216-8.
- JELÍNEK, M., et al. Antibacterial, cytotoxicity and physical properties of laser — Silver doped hydroxyapatite layers. Materials Science and Engineering C, Biomimetic and Supramolecular Systems. 2013, 33(3), pp. 1242-1246. ISSN 0928-4931. DOI: 10.1016/j.msec.2012.12.018.
- ZEIPL, R., et al. Properties of thermoelectric Ce0.09Fe0.67Co3.33Sb12/FeSb2Te multi-layered structures prepared by laser ablation. Thin Solid Films. 2013, 548(0), pp. 590-596. ISSN 0040-6090. DOI: 10.1016/j.tsf.2013.09.068.
- JELÍNEK, M., et al. Optical properties of laser-prepared Er- and Er,Yb-doped LiNbO3 waveguiding layers. Laser Physics. 2013, 0(23), pp. 1-5. ISSN 1054-660X. DOI: 10.1088/1054-660X/23/10/105819.
- JELÍNEK, M. Hybrid laser technology for biomaterials. In: JELÍNKOVÁ, H., ed. Lasers for medical applications. Abington Camprige: Woodhead Publishing. 2013, pp. 704-724. 1. vol. 37. ISBN 9780857092373. DOI: 10.1533/9780857097545.4.704.
- JELÍNEK, M., PODLAHA, J., and KOCOUREK, T. DLC Coated Textile Vascular Prostheses Tested in Sheep. In: Advanced Materials Research. International Conference on Biomaterial and Bioengineering. Hong Kong, 19.12.2012 - 20.12.2012. Durnten-Zurich: Trans Tech Publications. 2013, pp. 20-24. ISSN 1022-6680. ISBN 9783037855973. DOI: 10.4028/www.scientific.net/AMR.647.20.
- MIKŠOVSKÝ, J., et al. Micro and Macro Scratch and Microhardness Study of Biocompatible DLC and TiO2 Films Prepared by Laser. In: Advanced Materials Research. International Conference on Biomaterial and Bioengineering. Hong Kong, 19.12.2012 - 20.12.2012. Durnten-Zurich: Trans Tech Publications. 2013, pp. 25-29. ISSN 1022-6680. ISBN 9783037855973. DOI: 10.4028/www.scientific.net/AMR.647.25.
- URZOVÁ, J., et al. Treatment of Onychomycosis Using Radiation of Excimer Laser. In: Advanced Materials Research. International Conference on Biomaterial and Bioengineering. Hong Kong, 19.12.2012 - 20.12.2012. Durnten-Zurich: Trans Tech Publications. 2013, pp. 636-641. ISSN 1022-6680. ISBN 9783037855973.
- ZEIPL, R., et al. Thermoelectric Properties of Ce0.09Fe0.67Co3.33Sb12/FeSb2Te Multi-Layered Structures. Journal of Computer and Communications. 2013, 1(7), pp. 1-4. ISSN 2327-5219.
- KOCOUREK, T., et al. Silver-Doped Layers of Implants Prepared by Pulsed Laser Deposition. Journal of Computer and Communications. 2013, 1(7), pp. 59-61. ISSN 2327-5219.JELÍNEK, M. Functional planar thin film optical waveguide lasers. Laser Physics Letters. 2012, 9(2), pp. 91-99. ISSN 1612-2011.
- REMSA, J., JELÍNEK, M., and MIKŠOVSKÝ, J. PLD and RF discharge combination used for preparation of photocatalytic TiO2 layers. Applied Surface Science. 2012, 258(23), pp. 9333-9336. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2012.02.042.
- KUTÍLEK, P., et al. The evaluation and comparison of the practical adhesion strength of biocompatible nano and micro thin films by fuzzy logic [online]. In: 35th International Conference Telecommunications and Signal Processing. 35th International Conference on Telecommunications and Signal Processing. Prague, 03.07.2012 - 04.07.2012. Brno: VUT v Brně, Fakulta elektrotechniky a komunikačních technologií. 2012, pp. 489-493. ISBN 978-1-4673-1118-2.
- PROSECKÁ, E., et al. Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface StimulatesMesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts. Journal of Biomedicine and Biotechnology. 2012, 2012(0), pp. 1-10. ISSN 1110-7243. DOI: 10.1155/2012/428503.
- JELÍNEK, M., et al. MAPLE activities and applications in gas sensors. Applied Physics A: Materials Science and Processing. 2011, 105(3), pp. 643-649. ISSN 0947-8396. DOI: 10.1007/s00339-011-6629-0.
- KOCOUREK, T., et al. Evaluation of elastic properties of DLC layers using resonant ultrasound spectroscopy and AFM nanoindentation. Surface & Coatings Technology. 2011, 205(2), pp. 67-70. ISSN 0257-8972. DOI: 10.1016/j.surfcoat.2011.01.038.
- JELÍNEK, M., REMSA, J., and ZEZULOVÁ, M. Laser Deposition of TiO2 for Urethral Catether. In: Proc. of SPIE Vol. 7747 - 16th International School on Quantum Electronics: Laser Physics and Applications. 16th International School on Quantum Electronics: Laser Physics and Applications. Nessebar, 20.09.2011 - 24.09.2011. Bellingham: SPIE. 2011, pp. 774703-1-774703-8. ISSN 0277-786X. ISBN 978-0-8194-8237-2. DOI: 10.1117/12.885085.
- ZEZULOVÁ, M., et al. Study of Thin Films of LiNbO3 Using FTIR and Raman Spektroscopy. In: Proceedings of SPIE Vol. 8306 - Photonics, Devices, and Systems V. Photonics Prague 2011. Praha, 24.08.2011 - 26.08.2011. Bellingham: SPIE. 2011, pp. 91. ISSN 0277-786X. ISBN 978-0-8194-8953-1. 10.1117/12.910590.
- JELÍNEK, M., et al. Biomedical Properties of Laser Prepared Silver-Doped Hydroxyapatite. Laser Physics. 2011, 21(7), pp. 1265-1269. ISSN 1054-660X. 10.1134/S1054660X11130159.
- JELÍNEK, M., et al. Antibacterial Properties of Ag-Doped Hydroxyapatite Layers Prepared by PLD Method. Applied Physics A: Materials Science and Processing. 2010, 101(4), pp. 615-620. ISSN 0947-8396. DOI: 10.1007/s00339-010-5911-x
- JELÍNEK, M., et al. Diamond/Graphite Content and Biocompatibility of DLC Films Fabricated by PLD. Applied Physics A: Materials Science and Processing. 2010, 101(4), pp. 579-583. ISSN 0947-8396. DOI: 10.1007/s00339-010-5912-9.
- JELÍNEK, M., et al. Conductive Gas Sensors Prepared Using PLD. In: Proceedings of the NATO Advanced Study Institute on Nanotechnological Basic for Advanced Sensors. Science for Peace and Security. Sozopol, 30.05.2010 - 11.06.2010. Dordrecht: Springer. 2010, pp. 391-399. ISBN 978-94-007-0903-4. 10.1007/978-94-007-0903-4_40.
- JELÍNEK, M., et al. Biocompatibility and Sp3/Sp2 Ratio of Laser Created DLC Films. Materials Science and Engineering: B. 2010, 163(1-3), pp. 89-93. ISSN 0921-5107. DOI: 10.1016/j.mseb.2010.01.010.
- ZEIPL, R., et al. Properties of Thin N-type Yb0.14Co4Sb12 and P-type Ce0.09Fe0.67Co3.33Sb12 Skutterudite Layers Prepared by Laser Ablation. Journal of Vacuum Science and Technology A. 2010, 28(4), pp. 523-527. ISSN 0734-2101. DOI: 10.1116/1.34258037.
- JELÍNEK, M., et al. Doped Biocompatible Layers Prepared by Laser. Laser Physics. 2010, 20(3), pp. 562-567. ISSN 1054-660X. 10.1134/S1054660X10050087.
- JELÍNEK, M., et al. SiCx Layers Prepared by Hybrid Laser Deposition and PLD. Plasma Processes and Polymers. 2009, 6(1), 366-369. ISSN 1612-8850. 10.1002/ppap.200930803.
- KOPECKÝ, D., et al. Polypyrrole Thin Films for Gas Sensors Prepared by Matrix-Assisted Pulsed Laser Evaporation Technology: Effect of Deposition Parameters on Material Properties. Thin Solid Films. 2009, 517(6), 2083-2087. ISSN 0040-6090. DOI: 10.1016/j.tsf.2008.10.047.
- JELÍNEK, M., et al. Hybrid laser-magnetron technology for carbon composite coating. Laser Physics. 2009, 19(2), 149-153. ISSN 1054-660X. 10.1134/S1054660X09020017.
- JELÍNEK, M., et al. Highly oriented crystalline Er:YAG and Er:YAP layers prepared by PLD and annealing. Applied Surface Science. 2009, 255(10), 5292-5294. ISSN 0169-4332. DOI: 10.1016/j.apsusc.2008.08.037.
- JELÍNEK, M., et al. Pulsed Laser Deposition: Passive and Active Waveguides. International Journal of Materials & Product Technology. 2009, 34(4), 438-453. ISSN 0268-1900.
- JELÍNEK, M. Growth of Optical Waveguides by Pulsed Laser Deposition. Laser Physics. 2009, 19(2), 265-273. ISSN 1054-660X. 10.1134/S1054660X09020194.
- JELÍNEK, M., et al. Thin SiCx Layers Prepared by Hybrid Laser-Magnetron Deposition, Applied Physics A: Materials Science and Processing. 2008, 93(3), 633-637. ISSN 0947-8396. DOI: 10.1007/s00339-008-4727-4.
- KOCOUREK, T., et al. DLC Coating of Textile Blood Vessels using PLD. Applied Physics A: Materials Science and Processing. 2008, 93(3), 627-632. ISSN 0947-8396. DOI: 10.1007/s00339-008-4728-3.
- JELÍNEK, M., et al. Nanotechnologie Praha: Technologické centrum AV ČR, 2008.